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Setting realistic expectationsexplaining that maximum benefits may take 3 months to manifest and that gastrointestinal side effects typically improve with timeenhances treatment persistence and patient satisfaction with this therapeutic approach

Mechanistically, afamelanotide is a melanocortin-1 receptor (MC1R)-preferential agonist

Follow the schedule : Adhering to the prescribed injection schedule is crucial

This means choosing a pharmacy, vial size, and ordering cadence that removes uncertainty

By contrast, no significant differences were observed in response to GEP12 at 5 nmol/kg/day (food intake: mean difference 20.0 kcal/day, 95% CI 41.4 to 1.5 kcal/day, p = 0.067