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29 A mild increase in senescence markers was observed at 24 and 48 hours, suggesting early cellular stress response preceding death

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More significant changes including enhanced muscle mass, reduced body fat, and comprehensive body composition improvements typically become evident after three to six months of consistent therapy

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Clinical Importance: Oral semaglutide is the first oral GLP-1 receptor agonist, combining meaningful HbA1c reduction, clinically relevant weight loss, and favorable blood-pressure effects in a once-daily tablet