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As an example, Zepbound (tirzepatide), is approved by the FDA for chronic weight management in adults with obesity (BMI of 30 kg/m2 or greater) or overweight (BMI of 27 kg/m2 or greater) with at least one weight-related condition, which can include conditions other than type 2 diabetes
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When activated, AMPK may enhance insulin sensitivity, increase glucose uptake in skeletal muscle, suppress hepatic gluconeogenesis, and improve lipid metabolism
and Morgan, E.J., Biochem J
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