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Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer
Here we show that silencing of GSTO1 with siRNA significantly impairs cancer cell viability, validating GSTO1 as a potential new target in oncology
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By counteracting oxidative stress, it could potentially help minimize the appearance of wrinkles, fine lines, and other age-related skin changes
This might be due to unfavourable ionisation properties of the disulfide-containing peptide or the disulfide might negatively affect tryptic cleavage of the respective peptide before mass spectrometric analysis
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