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Importantly, not all variants confer increased risk: loss of function variants in HSD17B13, a lipid droplet-associated protein in hepatocytes, have been consistently associated with reduced hepatic inflammation and a lower risk of fibrosis and advanced liver disease [16]
Patients typically present with bilateral and symmetrical enlargement of the legs, with a clear demarcation at the ankles commonly referred to as the cuffing sign while the feet and hands remain unaffected
Both also carry a risk of pancreatitis, a serious condition
One practical concern: if your injection causes nausea and you have a child who wakes during the night, you will be dealing with nighttime parenting while nauseous
Adjusting your fiber intake alongside GLP-1 support requires a strategic approach
