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Most people have heard at least something about glucagon-like peptide 1 receptor agonists, more commonly known as GLP-1 medications, or GLP-1s

When you swallow a standard pill, it meets saliva, stomach acid, and bile

By promoting glucosuria and reducing hyperglycaemia, SGLT2 inhibitors dampened glucotoxicity, which indirectly resulted in an improvement of -cell function and peripheral insulin sensitivity [12]

Future studies should explore whether perioperative hydration protocols, electrolyte monitoring, or cardiovascular screening could help mitigate these risks while maximizing the benefits of GLP-1 agonists in orthopedic surgical populations

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