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10.1016/j.nantod.2022.101457 Nano Today 79 ZhengJ.XieY.RenL.QiL.WuL.PanX.et al (2021)

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Subgroup analysis indicated that homozygous mutations were associated with more severe impairment of long-term weight loss than heterozygous mutations, which explains why bi-allelic MC4R mutation carriers have poorer long-term outcomes than heterozygous carriers

In addition, DZN-induced oxidative stress in the testes

PGBH ranges from mild, in which neuroglycopenia resolves with dietary changes with or without acarbose, to severe, in which neuroglycopenia persists despite dietary changes and multiple drugs