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The FDA removed tirzepatide from the drug shortage list in December 2024 and semaglutide in February 2025, eliminating the primary legal basis for "essentially a copy" compounding of these substances
Visceral fat elevated, skeletal muscle adequate
Fatigue: Feeling unusually tired or fatigued can happen initially
Truncation of just two N-terminal residues of GLP-1 decreases affinity by 100300-fold and potency for cAMP signalling by 100010,000-fold 22
Overall, the treatments in this trial have undergone previous testing and are considered safe for most people
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