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Br J Pharmacol (2008) 154(2):38496

Danazol, a synthetic steroid with antigonadotropic and anti-estrogenic properties was the first FDA-approved treatment for endometriosis, but its use has been restricted in some regions due to safety concerns around liver toxicity and androgenic and teratogenic side-effects

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Selective NLRP3 inhibitors effectively protect against -synuclein and toxin-based models by lowering microglial activation, restricting T-cell recruitment, suppressing dopaminergic cell death, and enhancing behavioral outcomes

Experts also warn that the trend is far from harmless, with the World Health Organization (WHO) calling it a "global health problem that needs urgent attention" in 2023