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Given the enhanced efficacy of the 5FU + metformin combination in AKP organoid models in 3D (Fig
Ilyas Z, Perna S, Al-Thawadi S, Alalwan TA, Riva A, Petrangolini G, et al
Combining both interventions might intensify these effects, potentially affecting treatment adherence and quality of life
The combination has not shown any emergent toxicity beyond what would be expected from either peptide individually
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