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Lastly, we confirmed that cells surviving 5FU treatment do not increase mtDNA content to compensate for overwhelming mtDNA release (Extended Data Fig
(PubMed) Schmuth M, Wimmer MA, Hofer S, et al
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Weeks 14: 0.25 mg once a week Weeks 58: 0.5 mg Weeks 912: 1 mg Weeks 1316: 1.7 mg (if needed) Week 17 and beyond: 2.4 mg (maintenance) Weeks 14: 2.5 mg weekly (starting dose) Week 5+: 5 mg weekly Increase by 2.5 mg every 4 weeks if needed Maximum: 15 mg weekly Your provider will help you determine the right pace based on how youre responding
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