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It also promoted the expression of Arg-1, IL-10, and TGF-, inhibiting ferroptosis and inducing BV2 cell polarization toward the M2 phenotype, thereby mitigating BV2 cell injury
In the main trial approximately 47% of participants discontinued treatment due to adverse events, depending on the dose, with higher doses linked to increased discontinuation
a separate Merck Phase 2b trial in hip-fracture patients (Adunsky et al., 2011, PMID 21067829) was stopped early after a cardiac safety signal emerged
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Drigen R
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