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The last GSH synthetic process is the one depending on the conversion of the oxidized dimer GSSG to 2 reduced GSH molecules in cells by glutathione reductase (GR), an ubiquitous enzyme of the family of disulfide reductases, in the presence of NADPH and flavin adenine dinucleotide -FAD-
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doi: 10.1016/j.biopha.2020.110590 91 Snchez-MartnVMoralesPIriondo-DeHondAHospitalXFFernndezMHierroEet al
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It is possible that a longer period of time or a specific population of PCOS patients with excessive obesity or metabolic syndrome is needed to observe the positive effects of L-carnitine supplementation on the oocyte quality, so further clinical trials considering these issues are suggested
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