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The main limitations of the study are the lack of a control group, the single-center design, and the low sample size, which, although statistically adequate, does not allow for a more in-depth analysis of muscle mass stratified by patient gender
(The very first GLP-1 drug on the market, exenatide, had to be injected twice a day when it was released, in 2005the field has come a long way.) The medications are also given at levels much higher than natural GLP-1 ever reaches in the bloodstream
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