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Mounjaro is a dual GIP and GLP-1 receptor agonist licensed in the UK for type 2 diabetes and weight management
it promotes lipid deposition in mice subcutaneous fat cells, it does not affect gastric emptying, and its effect on blood glucose is impaired in chronic hyperglycemia
However, in the striatum, which is located in the subcortical forebrain, insulin influences dopamine reuptake and release, with IR opposing these effects, impacting neuronal excitatory projections [90]
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