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The results may be reconcilable by the existence of distinct Gipr -expressing target cell populations with different physiological roles and responsiveness

GI side effects in clinical trials typically resolved within 23 weeks, but if symptoms persist beyond four weeks at a reduced dose, discontinuation is warranted

55 The phase 3 REDEFINE-3 trial will further assess the impact of cagrilinitide/semaglutide on major adverse cardiovascular events in people with obesity (with or without T2DM) and established CVD (clinical trial number NCT05669755

doi:10.1097/MD.0000000000017186 Monteleone, P et al

doi: 10.1186/s12890-021-01422-9 292 WestA