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Current understanding relies heavily on extrapolation from consistent animal model results and accumulating anecdotal human reports

A meta-analysis of randomized, controlled trials found that DHEA supplementation significantly decreased cortisol levels (Chen 2021)

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They cause nausea, fatigue, and gastrointestinal distress in a significant percentage of users

The availability of this pill could make weight-loss treatment more accessible to a large number of Americans who have avoided injectable options due to expense, discomfort with needles or rigid dosing rules