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Description

Molecular identification and characterization of A and B forms of the glucocorticoid receptor

Hope KJ, Jin L, Dick JE

Regul Pept 151(13):123129

AbeteIGoyenecheaEZuletMAMartnezJA

Two main strategies have been used to modify the sequences of semaglutide and tirzepatide (red circles) and increase their bioavailability: 1) removal of the DPP-4 cleavage site, replacing alanine with an analogous molecule (-aminoisobutyric acid (Aib)), but not recognized by the enzyme