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43% of people on a GLP-1 reach the 1.2 g/kg protein target 4665% stop within 12 months cost and side effects lead ~ of lost weight tends to return within a year without a plan On muscle loss the honest version: About 40% of the weight lost in the STEP-1 trial was lean mass (Neeland 2024)

Patients taking warfarin should have more frequent INR monitoring when initiating GLP-1 therapy

Winner for liver disease: Survodutide (direct mechanism, breakthrough therapy designation, NEJM-published data)

The concept also pushes brain-health research toward treat the whole person not just treat the brain. That alignment is powerful

It also assists in weight reduction and thence, reduce the core problem of insulin resistance in these patients