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While immunotherapy has revolutionized the treatment of many solid tumors, its application to osteosarcoma has yielded modest clinical benefits, primarily because these tumors are immunologically cold (57)
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doi: 10.1080/22221751.2024.2377584 413 TingD
Eur J Nutr 2015 Mar;54(2):251-263
For example, MEK inhibition leads to strong overrepresentation of ERK1/2 motif as expected, GSK3 inhibition down-regulates sites that conform to the known GSK3 motif, and mTOR inhibition down-regulated sites with the known mTOR substrate motif as well as substrate sites of its main downstream kinase p70S6K
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