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Similar content being viewed by others 1 Introduction With the emergence of the SARS-CoV-2 pandemic in December 2019 in the Wuhan province of China as its epicenter, it brought a wave of morbidity and mortality worldwide, spreading rapidly to more than 190 nations infecting over 180 million people 1,2,3,4,5

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In summary, the GSH-GSSG redox cycle does not exist in isolation, but rather operates as a dynamic equilibrium system that is highly coupled to the NADPH metabolic network

Targeting any receptor with small molecules is inherently challenging because of basic biology

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