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However, a breakthrough came with the observation that TICs, rather than the bulk of differentiated tumor cells, thrive in 3D gels [23, 24], offering an opportunity to uncover signaling pathways specific to TIC growth and identify TIC-specific therapeutic targets

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At completion, participants who received the extract had significant decreases in HbA1c (8%), fasting serum glucose (12%), insulin levels (44%), insulin resistance (19%), body mass index (7%), abdominal body fat (23%), and serum leptin (43%) compared with their levels at the beginning of the study

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Polypodium leucotomos extract (480 mg twice daily)