Human NAT2 is a xenobioticmetabolising enzyme that provides a major route of detoxification of drugs such as isoniazid (an antituberculotic drug), hydralazine and endralazine (antihypertensive drugs), a number of sulphonamides (antibacterial drugs) (Kawamura et al., 2005), procainamide (antiarrhythmic drug), aminoglutethimide (an inhibitor of adrenocortical steroid synthesis), nitrazepam (a benzodiazepine) and the antiinflammatory drug dapsone (Ginsberg et al., 2009, Butcher at al., 2002)
Swiss Chems is one of the few vendors offering oral capsule formats, which is the practical draw for researchers who want non-injectable options: 5-Amino-1MQ an NNMT-inhibitor research compound, in capsules
Vorinostat is not a classical mTOR antagonist but has been used clinically in combination with mTOR inhibitors or to modulate mTOR-related pathways (165)
Until regulatory pathways evolve or academic institutions prioritize this research, human trial data will remain sparse
In: Luch A, editor