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As previously stated in this review, GSH is the most abundant intracellular antioxidant and plays major roles in the antioxidant defense system and maintenance of redox homeostasis in both the PNS and CNS (Hristov BD, 2022)
Transfusion independence and HMGA2 activation after gene therapy of human -thalassaemia
However, unlike selenium, unithiol and succimer lack the ability to penetrate the CNS, so restoration of selenoprotein activity in the brain following administration of the thiol chelators would not be expected [Citation8]
Gastroenterology 152 , 17281738 (2017)
In terms of mechanism, two key pathways are mainly responsible for activating apoptosis: the intrinsic pathway (mitochondria-mediated pathway) and the extrinsic pathway (death receptor-mediated pathway) (101, 102)
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