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A large number of acute (2-weeks) or long-term (90-days) oral EGT supplementation (0.9% concentration) experiments conducted on Sprague-Dawley rats did not show reproductive and developmental toxicity (Turck et al., 2016)

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Its well-tolerated and considered safe when used under medical supervision

They are also contraindicated in those with personal or family history of medullary thyroid carcinoma and those with multiple endocrine neoplasia type 2