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Nature 243 , 290293 (1973)

The GHK-Cu peptide (Copper Tripeptide-1) is widely researched as a regenerative signaling molecule involved in tissue repair and cellular renewal

Hydrobiologia 850, 119

Long-term follow-up studies are needed to assess durability of therapeutic effects and to identify any delayed adverse effects or complications that might not be apparent in shorter-term investigations

What this means in practice: topical GHK-Cu stays localized in the epidermis and upper dermis for 4896 hours, with measurable peptide concentrations persisting in skin biopsies long after serum levels would have cleared from an injected dose