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Native IGF-1 binds IGFBP-3, the dominant carrier protein in circulation, with a dissociation constant in the low nanomolar range (Kd approximately 0.1 to 1 nM in most published binding assays)

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In clinical practice, compound prescriptions can be flexibly adjusted on the basis of the stage of disease progression

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This is where supplementation gets complicated

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doi:10.1016/j.cmet.2017.11.003 55

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