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doi: 10.1016/j.impact.2022.100411 19 JamwalS.KumariA.VeeragurunathanV.PrasadK.GhoshA.KumarR
Carbon 81 , 158166 (2015)
IGF1, which is mainly expressed in the hepatic tissue, can directly inhibit GH secretion in the somatotrophs of fish (50, 96, 97), birds (98, 99) and mammals (87, 92, 100), through a longloop negative feedback (by acting on the pituitary and/or on GHRH in the brain, Figure 1 ), but also indirectly by enhancing the hypothalamic release of somatostatin (101), and is considered the other major endocrine and local effector of the GH/IGF axis
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