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This acylation is the property most often studied in comparative work against non-acylated GLP-1 analogs

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Semaglutide GLP-1 is an active ingredient in Ozempic and Wegovy, both brand-name versions of semaglutide GLP-1 that bind to the glucagon-like peptide-1 (GLP-1) receptor

The efficacy of setmelanotide may not be sufficient for POMC-MC4R deficient patients because body weight reduction ratio of semaglutide and tirzepatide were 12.4 and 17.8%, respectively in clinical study as compared with that of setmelanotide, 5.2% [[18, 19, 23]]

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