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16 High doses have also been associated with gastrointestinal symptoms such as diarrhea and nausea

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The approved uses of this class are type 2 diabetes, chronic weight management, and, for several agents, reduction of cardiovascular risk

Ongoing supervision with baseline labs and periodic metabolic monitoring is treated as part of the package

These data reveal that distinctions in peptide N-terminal interactions and dynamics with the GLP-1R transmembrane domain are reciprocally associated with differences in the allosteric coupling to G proteins