Some of the other possible side effects associated with peptide therapy for Hashimotos include: Itching, numbness, or tingling at the injection site Dry mouth and increased hunger Changes in skin pigmentation, such as darkening of moles or increase in freckles Water retention, high blood pressure, severe kidney pain, joint pain, and weight changes Gastrointestinal issues like nausea, vomiting, and diarrhea, particularly with peptides affecting the digestive system Headaches Mood changes Swelling in the extremities In some cases, abuse of peptide hormones can lead to more serious health issues, such as motor paralysis, skeletal muscle damage and loss, diabetes mellitus, hypothyroidism, arterial hypertension, and increased risk for atherosclerosis, blood clots, osteoporosis, and cancer

Officials consistently point to adults over 65 living alone, infants and young children, pregnant people, people with heart, lung, or kidney disease, people taking medications that impair sweating or fluid balance, outdoor workers, and residents without working air conditioning
Ploy Pitayanon, MD, licensed by the Medical Council of Thailand At a Glance Peptide BPC-157 (Oral) Category Gut Health Dosage 250 to 500 mcg per day, physician-prescribed
The idea that you must inject it locally for a local injury is, in our expert opinion, a pervasive myth that isn't supported by the peptide's known mechanism of action
Potential degradation: Depending on formulation, some BPC-157 can be degraded by stomach acid before reaching the small intestine