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Caspase-3 activity in HepG2 cells treated with aspirin and after manipulation of GSH levels by BSO and NAC was measured using DEVD peptide conjugated to p-nitroanaline as described in the vendor's protocol (Figures 8A, B)
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Notably, GLP-1RA characterized by signaling bias favoring cAMP production over beta-arrestin recruitment has been regarded as more effective in controlling glucose and body weight in experimental mice compared to unbiased agonists [43, 44]
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