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By binding to GLP-1 receptors, these medications enhance glucose-dependent insulin secretion from pancreatic beta cells, suppress inappropriate glucagon release, slow gastric emptying, and promote satiety through central nervous system pathways

Joint pain and muscle pain have also been reported, though these may be related to rapid body composition changes rather than direct drug effects

Standard protocol: Cycle length: 34 weeks on, 4 weeks off minimum Some protocols: 21 days on, 4 weeks off (the "21-day cycle") More conservative: 2 weeks on, 4 weeks off Use the off-weeks to let receptor density recover

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Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies