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For GI-local goals, oral route animal data is reasonably supportive

Effects of once-daily subcutaneous semaglutide on fibrogenesis/fibrosis markers SMA ( a, d ), Col-I 1 ( b, e ) and PSR ( c, f ) in DIO-MASH mice ( a-c ) and CDA-HFD mice ( d-f )

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doi: 10.1681/asn.20203110s133c 149 PiccaAFaitgJAuwerxJFerrucciLD'AmicoD