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3 Results 3.1 Nitazoxanide improved liver function in rats with MTX-hepatotoxicity As depicted in Figure 2, an impaired liver function was observed in the MTX group compared to CTRL, as indicated by significantly elevated serum liver enzymes
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introduction of two random mutations of Y444A and G484A to D433N resulted in up to 50-fold increase in catalytic efficiency for GL-7-ACA substrate (Yamada et al., 2008)
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