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One randomized controlled trial compared the effects of Pycnogenol to no treatment in 92 individuals with mild-to-moderate, sudden-onset, one-sided tinnitus of unknown origin lasting at least two weeks

This isolated mechanism made it an appealing subject for early obesity research, since it theoretically offered a way to study fat metabolism separately from broader GH-axis activity

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Although most of these side effects tend to fade with time, seeking medical advice if they persist or worsen is recommended

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