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Ferroptosis is mediated by multiple mechanisms including lipid peroxidation, iron overload and dysfunction of the antioxidant system (Fig

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Patients with GPX4 overexpression had a reduced 5-year OS of 73% compared to 97% in patients with normal GPX4 expression (HR 2.95

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Suspected adverse reactions to medicines including those received in clinical trials can also be reported via the MHRA Yellow Card Scheme at yellowcard.mhra.gov.uk

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