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However, larger and longer-term studies are still lacking, making it difficult to draw firm conclusions

Incubation of NFT with cell or tissue homogenates, microsomal preparations, or isolated mitochondria revealed one-electron reduction of NFT to yield an NFT radical anion ( NFT ) by flavoprotein-reductases such as xanthine oxidase, aldehyde dehydrogenase, thioredoxin reductase, cytochrome b 5 reductase, and cytochrome P450 reductase (CYPOR) (Miller et al

Amodiaquine-induced oxidative stress in a hepatocyte inflammation model

Cell viability was studied using the AlamarBlue test

For all the aforementioned experiments, the Dual-Luciferase Reporter Assay System (Promega Corporation) was used to measure luciferase activity strictly according to the manufacturers instructions