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In vitro studies have examined its interactions with keratinocytes, fibroblasts, and melanocytes, the three primary cell types of the skin
Diabetologia 62 , 12511256 (2019)
We further revealed a pivotal role of immune response regulated by TGF- pathway in contributing to lifespan extension following mrps-5 RNAi, providing additional understanding of the mechanism and underscoring the beneficial effects of mitochondrial translation repression
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Serious but rare adverse effects include pancreatitis, gallbladder disease, acute kidney injury (usually secondary to dehydration from gastrointestinal symptoms), and hypoglycemia when combined with insulin or sulfonylureas
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