For weekly medications, missing one to two doses (one to two weeks) is generally acceptable and wont significantly impact long-term outcomes
Turmeric at food amounts is safe, but concentrated supplements can rarely cause liver damage
However, a one-year randomized, double-blind, placebo-controlled trial in 253 elderly (65 years) adults with elevated homocysteine levels found that B vitamin supplementation (1,000 g/day of folate, 10 mg/day of vitamin B 6 , and 500 g/day of vitamin B 12 ) did not improve measures of cognitive function, including memory, despite lowering homocysteine levels (116)
The good news is that vitamin B12 is a water-soluble vitamin, meaning any excess is naturally excreted by the body
Available from Accessed 15th July 2024 Mays EP Jr (2021) Increasing vitamin B12 screening among patients with type 2 diabetes on long-term metformin therapy