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It is important to remember that the majority of the current evidence is from animal studies or preliminary clinical trials and that to date, there is little information available on the side effects
Years of research on the safety and effectiveness of the drugs is required
Stress-inflammatory/oxidative pathway activation results in increased transforming growth factor- (TGF-) signaling, which activates SMAD3 and increased NADPH Oxidase 2(NOX2) expression and activity at the RyR2 channel, leading to oxidation and calstabin 2 depletion from the channel macromolecular complex
(source) Singh, Shivani