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In a referral related to safety of medicines, the PRAC is requested by a Member State or the European Commission to conduct a scientific assessment of a particular medicine or class of medicines on behalf of the EU

This phenomenon, known as early worsening of diabetic retinopathy, has been documented with various diabetes treatments and is not unique to GLP-1 receptor agonists

Although a number of biological activities have been attributed to various allicin-derived compounds, it is not yet clear which of these compounds or metabolites actually reaches target tissues (5)