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50 & Target Kd: 65 pM (HGF) [1] In Vitro Dihexa binds with high affinity to HGF and both dihexa and its parent compound Norleucine 1-AngIV induce c-Met phosphorylation in the presence of subthreshold concentrations of HGF and augment HGF-dependent cell scattering

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Weeks 1-4 energy and sleep changes are the most commonly reported subjective endpoints during titration

The combination protocol increases the number of dose escalation events (since you are titrating two compounds), which may mean more frequent but generally mild headaches

Jilin Provincial Natural Science Foundation General Project (Grant NO.YDZJ202301ZYTS102)