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The preclinical animal model data suggested that the glucose-lowering, lipid-lowering and insulin secreting effects were greater than those in GLP-1 receptor agonists [50]
Small-molecule GLP1RAs promise oral bioavailability and scalable manufacturing, but their selective binding to human versus rodent receptors has limited mechanistic studies 4,5,6,7,8,9
Wakkach, A
2024 L.E.K
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Combined treatment with DFX-DFO rapidly reduces myocardial and hepatic iron concentrations and significantly improves myocardial function and ejection fraction in patients with severe transfusional myocardial siderosis (NCT01254227)
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