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For detoxification and liver support, glutathione is irreplaceable it's literally the cofactor that phase II liver enzymes require to function
For instance, a cheap glutathione IV treatment can be made from glutathione with a low concentration, hence needing more treatments
Many people, including those over 50, on PPIs or metformin, or with GI conditions, produce insufficient intrinsic factor
Kyono, K., Hashimoto, T., Kikuchi, S., Nagai, Y
However, we now know that these long needles are excessive
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