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10.1152/physrev.00018.2018 Physiol

Askarpour, M., et al

Kachhawaha K, Singh S, Joshi K, Nain P, Singh SK

l_4), iv1iv86

Large hydrophilic chelators, such as DFO (a highly polar molecule with a molecular weight of 560 Da), exhibit poor BBB permeability when administered intravenously, remaining in the circulation and extracellular space, while only minimal amounts can cross into the brain parenchyma