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Oral administration of LSN3353871 to mice expressing human Lp(a) resulted in dose-dependent increases in the circulating levels of LSN3353871 and dose-dependent decreases of up to 78% in the levels of Lp(a), with a median effective dose (ED 50 ) of 14 mg kg 1 twice daily (BID) within five days of dosing
Next-generation sequencing of duplication CNVs reveals that most are tandem and some create fusion genes at breakpoints
While many ubiquitin ligases label proteins with ubiquitin chains to mark proteins for degradation by the proteasome, Parkin has been shown to mark dysfunctional mitochondria for degradation by mitophagy
10.1016/j.plaphy.2010.08.016 Plant Physiol
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