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How well it works: in the phase 3 OASIS 4 trial, adults taking the 25 mg pill for around 64 weeks lost on average about 16.6% of their body weight when they took it as intended (about 13.6% across everyone regardless of how consistently they took it), compared with roughly 2% on placebo

Therefore, we speculated that DMF could affect 2OG or 2HG levels to affect DNA methylation and revisited the initial LC-MS analyses which showed there are significantly reduced levels of 2HG, but not 2OG after DMF treatment (Fig