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About 15% of people report headaches

Both amounts remain within established safety thresholds for most healthy adults.46 47 Still, its worth keeping in mind especially for people who already supplement folate or vitamin D separately that combination products offer less flexibility when adjusting servings

Designing future studies may require careful attention to which endpoint is primary, as that will dictate whether a lower, moderate, or higher dose is emphasised

Individuals with liver or kidney disease should exercise caution and seek medical advice before use