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Beyond sleep, DSIP research has revealed potential applications in pain management (showing analgesic effects when administered intracerebroventricularly), addiction treatment (alleviating withdrawal symptoms in 97% of opiate-dependent and 87% of alcohol-dependent patients in one trial), antioxidant defense, and even stroke recovery
This temporary disruption typically resolves as your system adjusts, but practical strategies can ease the transition: maintain consistent sleep and wake times, avoid large meals within 3 hours of bedtime (already easier on GLP-1), and limit screen time 30 minutes before sleep
Tirzepatide BNF monograph (includes MHRA/CHM advice on GLP-1 receptor agonists and pancreatitis)